The Ottoman surrender of the Acropolis, the successive but ineffective attempts of the revolutionaries to conquer the forts of Chalkis and Karystos in Euboea, particularly in 1823-1824, the conflict between the government with Odysseas Androutsos, the failure of the Ottomans to subjugate the rebellious region and finally the failure of the revolutionaries to consolidate their domination of east-central Greece - these were the main threads of the years that followed the outbreak of the Greek Revolution.

The Acropolis was surrendered by the Ottoman garrison on 10 June 1822, after many months of siege. The expedition of Mahmud Dramali Pasha, which advanced almost unimpeded toward Boeotia and Attica at the end of June and which brought destruction and fear in its wake, did not result in the reoccupation of the Acropolis. News of the march of Dramali caused the massacre of many Muslim inhabitants of Athens, in violation of the terms of capitulation which stipulated they should be transported in safety to Asia Minor. Later, the town was deserted and several hundreds of troops remained in the Acropolis. However, Dramali did not move to Athens. After burning Thebes (1 July), he preferred to hurry to the Peloponnese with all his troops. Thus, the Acropolis remained under the control of the revolutionaries. The impressive passing of Dramali in the summer of 1822 effected but did not repress the uprising in east-central Greece. In the following years other Ottoman officials marched out in the region. Parnassos and Elikon, Lokris and the district of Salona (Amfissa), Livadeia and Thebes saw hard battles and the victories were shared betweeen both sides, Ottoman and Greek. In these years neither side succeded in gaining complete control of the region. Under these conditions the possession of the Acropolis acquired an increasing significance. Gradually, it became the centre of the Revolution and that of military operations in east-central Greece.

A highly important domestic political incident occurred in the Acropolis during the Greek Revolution. This was the murder of Odysseas Androutsos at the beginning of June 1825. Particularly from 1824 onwards, Androutsos, the most powerful military man since the beginning of the uprising was pushed out of the limelight. Furthermore, he was the target of political agents within the new social and political balance of power that was forming in the revolutionary administration, especially Kolettis, who saw in Androutsos a strong obstacle in his effort to control the armed men of east-central Greece. Thus, with the favour of Kolettis, Ioannis Gouras gained distinction among the armed men of the region. Gouras had been a deputy chief of Androutsos and a warrior. This was proven in the summer of 1821 in a very important battle for the Revolution, the Battle of Vasilika. When Androutsos left the Acropolis in 1823 to organize operations mainly in Euboea (the sieges of Karystos and Chalkis), he left Ioannis Gouras as garrison commander. The latter was little by little isolated from Androutsos and connected to I. Kolettis and the so-called Kranidi government. Thus he was found on the side of the winners of the civil war. He contributed decisively to this victory by invading the Peloponnese and defeating the troops of Kolokotronis and those of the notables of the Morea in the summer of 1824. A few months later, at the end of 1824, it was Ioannis Gouras who was charged with the arrest of Androutsos. The arrest of Androutsos (he was charged with treason) was followed by his imprisonment in the Acropolis. He remained there a few months until the beginning of June when he was assassinated in conditions that have never been clarified.