Argissa is situated on the banks of the river Peneios, approximately 4,5 kilometres to the west of Larisa. The site was inhabited during the Neolithic and Bronze Ages, leaving behind cultural remains several metres thick. During excavations (1956) a layer 30-45 centimetres thick, at a depth of 8 metres, dating from the Pre-Pottery Neolithic, was located and is one of the few examples of this transitional period.

The houses of the first farmers and stock-rearers of Argissa were oval subterranean huts, dug partly in the ground. Post holes indicate that they were huts with walls made of posts. Floors were paved with clay or pebbles and had hearths.
Blades of flint and bladelets of obsidian, tools of polished stone, bone tools, charred grains of cereals and pulses, and numerous animal bones constitute the mobiliary finds. A systematic study of the finds was necessary in order to reveal aspects of the economy, in a period when man passed to the controlled production of his food. A study of the stone tools has shown that obsidian reached Argissa in the form of cores, from which blades were cut off with the pression method. This method does not follow the tradition of the Mesolithic stone industry, which applied percussion techniques for the manufacture of blades and bladelets and must have originated from elsewhere, supporting the view that the Neolithic way of production was not gradually developed in Greece, but was imported from Asia Minor.